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This video was recorded at BBCI Workshop: Advances in Neurotechnologies, Berlin 2012. The detectability of spikes defines a striking contrast between invasive (microscopic) and noninvasive (macroscopic) neurophysiological measurements. While noninvasive records are dominated by summed postsynaptic potentials reflecting neuronal input, invasive electrodes can provide easy access also to the very output of neuronal computation – spikes. This micro/macro gap, however, has been narrowed gradually over the last years by combining special physiological paradigms with neurotechnological advances. To convey the gist of this research agenda on high-frequency spike-related EEG/MEG the tripartite lecture will (i) address the basic neurophysics of near-field and far-field signals distinguishing slow from fast neuronal activities, (ii) elaborate on high-frequency (600 Hz) somatosensory evoked responses serving as 'workhorse' to establish the feasibility of noninvasive spike-related recordings also in non-specialised labs, and (iii) report on recent neurotechnological progress providing a unique opportunity for high-resolution scalp mappings of EEG activities even above 1 kHz which reflect noninvasive correlates of human neocortical population spike responses.

Disciplines:

• Science and Technology

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