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Nothing can happen in biology unless something binds to something else. Although much of the effort in bioinformatics to date has focused on the detection of homology or the deduction of structure and/or function from sequence, in the long run, for bioinformatics to make a real contribution to drug design and cell biology, it will be necessary to be able to predict what other molecules a given gene product will bind to and how tight that binding will be. At present, no one knows how to do this routinely. The collection of large data sets for molecular interactions will help discover predictable features of molecular interactions.

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