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As we enter the 21st century, we stand at a major inflection point for biology and medicine-the way we view and practice these disciplines is changing profoundly. These changes are being driven by systems biology, a new approach to biology, and which will increasingly transform medicine from disease-driven and reactive to health-driven and predictive and preventative. Systems biology and predictive and preventative medicine are both are data driven and, accordingly, both require new tools for making large numbers of measurements. Microfluidics, nanotechnologies and molecular imaging will revolutionize our ability to generate comprehensive data sets that span from individual cells to patients. In this talk I will describe a systems biology approach toward disease, using cancer as the model. I will then describe our progress toward developing `informative' diagnostic tools based upon the multiparameter analysis of blood cells and serum, with the goals of achieving early stage detection of various cancers.

Disciplines:

• Science and Technology  / Nanotechnology