The Cyber-Physical System (CPS) is an emerging computing technology that involves sensing, computing, controlling, and communication between physical components (e.g., smart sensors, devices, systems, and human beings) and cyber components (e.g., cloud and big data centers). The sensing, controlling, and interaction have significant promises toward the realization of the current and future therapy system, where cloud resources and data centers are expected to process complex therapeutic heterogeneous big data. Although the CPS has great potential for sensing and controlling therapy, energy efficiency is crucial for such a therapy system for its sustainability, especially for elderly people who cannot physically optimize energy consumption. To this end, this article proposes an energy-aware cyber-physical therapy system (T-CPS), which incorporates smart things and devices in both the physical and cyber worlds for therapy sense. To provide energy-efficient, affordable therapeutic services, the T-CPS framework uses multi-modal sensing for the provision of therapy sensing, therapy playback, annotation, visualization, and energy efficiency. The framework was evaluated by real subjects along with several therapists. Test results show the usefulness of the proposed T-CPS framework.