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The monograph introduction discusses the health care-associated infections (HAIs) problem, imperatives for the elimination of HAIs, background on central line-associated bloodstream infection (CLABSI) terminology, CLABSI-related morbidity and mortality costs, and the preventability of CLABSIs. Key points include the following:

• HAIs occur throughout the world, affecting hundreds of millions of patients each year.¹ These infections are not only costly to individuals and health care systems; they can significantly increase morbidity and mortality in developed countries² and in developing countries.^3,4

• There is growing recognition that many HAIs are largely preventable when evidence-based practices are followed consistently over time.

• Central venous catheters (CVCs) are the most frequent cause of health care-associated bloodstream infections.⁵

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