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By stimulating adrenal corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and stress response. In this Research Topic, we will discuss the various mechanisms involved in ACTH action, from ACTH binding to its receptor to steroid secretion, as well as the pathological consequences of the disruption of specific components of the pathways. A particular attention will be given to how various kinases, phosphatases and cytoskeleton-associated proteins interact to ensure homeostasis and/or meet physiological demands. The Research Topic will include: - Growth-promoting activities of ACTH; - Acute and chronic regulation of steroid secretion by ACTH, including effect of ACTH on circadian rythms of secretion. - Properties of ACTH binding to its receptor to signaling pathways, including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and function. - Intracellular cascades of signaling: Although cAMP is the main second messenger involved in ACTH action, several types of intracellular kinases, phosphatases and phosphodiesterases, are also involved. - Effects of ACTH on electrical properties of adrenocortical cells: The importance of ionic activity in ACTH action began to emerge as a result of the selective disruption of ion channels genes in transgenic mice. In some instances, these knockout mouse m...

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