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This article describes how cancer has become the leading cause of death, followed by ischaemic heart disease since the industrial revolution.  It discusses how lifestyle has become more important than environment in causing cancer, and although cancer mortality is falling in the developed countries as a result of earlier detection and advances in treatment, incidence continues to rise.  Unfortunately, the burden of cancer is falling more and more on those countries with limited capacity to prevent, diagnose, treat or palliate cancer whhich now account for 70% of global deaths from cancer.  The importance of all aspects of cancer control and global cooperation is emphasized.

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